منابع مشابه
Role of the lever arm in the processive stepping of myosin V.
Myosin V is a two-headed molecular motor that binds six light chains per heavy chain, which creates unusually long lever arms. This motor moves processively along its actin track in discrete 36-nm steps. Our model is that one head of the two-headed myosin V tightly binds to actin and swings its long lever arm through a large angle, providing a stroke. We created single-headed constructs with di...
متن کاملTreatment of bimaxillary protrusion with lever-arm mechanics and micro-implant anchorage.
Dr. Hong is Chairman, Department of Orthodontics, Chong-A Dental Hospital, and Clinical Professor, Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, Korea. Drs. Lim and Heo are in the private practice of orthodontics in Seoul. Dr. Heo is also a Clinical Professor, Department of Dentistry, College of Medicine, Hallym University, Chuncheon, Korea. Dr. Ahn is an As...
متن کاملEngineered myosin VI motors reveal minimal structural determinants of directionality and processivity.
Myosins have diverse mechanical properties reflecting a range of cellular roles. A major challenge is to understand the structural basis for generating novel functions from a common motor core. Myosin VI (M6) is specialized for processive motion toward the (-) end of actin filaments. We have used engineered M6 motors to test and refine the "redirected power stroke" model for (-) end directional...
متن کاملElastic lever-arm model for myosin V.
We present a mechanochemical model for myosin V, a two-headed processive motor protein. We derive the properties of a dimer from those of an individual head, which we model both with a four-state cycle (detached; attached with ADP.Pi; attached with ADP; and attached without nucleotide) and alternatively with a five-state cycle (where the powerstroke is not tightly coupled to the phosphate relea...
متن کاملEssential "ankle" in the myosin lever arm.
C ellular motors are fascinating machines that function by undergoing successive conformational changes that require joints in their structure. Where these are located is particularly critical for molecular motors that produce force with relatively rigid lever arms, such as myosins (1). A long-standing paradox in myosin function may finally be understood from structural insights provided by Coh...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.05.026